The NFL Week 5 schedule features some pivotal showdowns, with the Dallas Cowboys at San Francisco 49ers at the forefront.
But don't forget about the Philadelphia Eagles at Los Angeles Rams and Kansas City Chiefs at Minnesota Vikings games, which have the potential to be thrillers, as do several other Week 5 NFL games.
Who will win each game this week?
Check out our NFL picks and predictions for the Week 5 NFL schedule, which begins with the Chicago Bears at Washington Commanders on Thursday Night Football and concludes with the Green Bay Packers at Las Vegas Raiders on Monday Night Football.
The Cleveland Browns, Los Angeles Chargers, Seattle Seahawks and Tampa Bay Buccaneers have byes this week.
All times MST. Click on each game for more picks and predictions for that NFL Week 5 matchup.
NFL Week 5 picks: Bears at Commanders | Jaguars at Bills | Texans at Falcons | Panthers at Lions | Titans at Colts | Giants at Dolphins | Saints at Patriots | Ravens at Steelers | Bengals at Cardinals | Eagles at Rams | Jets at Broncos | Chiefs at Vikings | Cowboys at 49ers | Packers at Raiders
NFL Week 5 predictions:ESPN matchup predictor's picks, win probabilities for games
Thursday Night Football prediction
Chicago Bears at Washington Commanders, 5:15 p.m., Amazon Prime Video (stream with Amazon Prime Video)
The Commanders impressed us in their overtime loss to the Eagles last week. Their defense could feast on the Bears' offensive line.
Prediction: Commanders 24, Bears 21
NOTE:Every Sunday and Monday NFL game can be streamed locally on FUBO, click here for a free trial
NFL power rankings Week 5:San Francisco 49ers, Philadelphia Eagles lone undefeated teams
Sunday game in London prediction
Jacksonville Jaguars at Buffalo Bills, 6:30 a.m., NFL Network (stream with free trial from FUBO)
The Jaguars looked good in their NFL Week 4 London win over the Falcons, but the Bills are not the Falcons.
Prediction: Bills 28, Jaguars 20
NFL Week 5 odds:Point spreads, moneylines, over/unders for betting on games
Sunday early football games predictions
Houston Texans at Atlanta Falcons, 10 a.m., CBS (stream with free trial from FUBO)
Are C.J. Stroud and the 2-2 Texans for real? We'll find out if they can make it three wins in a row on Sunday. We think they can.
Prediction: Texans 21, Falcons 17
Carolina Panthers at Detroit Lions, 10 a.m., FOX (stream with free trial from FUBO)
We don't think the Panthers are going to lose every game this season, but we don't think their first win will come in Week 5.
Prediction: Lions 30, Panthers 17
Tennessee Titans at Indianapolis Colts, 10 a.m., CBS (stream with free trial from FUBO)
The Titans are 2-0 at home and 0-2 on the road. Since they play this game on the road, we'll go with the home team.
Prediction: Colts 23, Titans 20
New York Giants at Miami Dolphins, 10 a.m., FOX (stream with free trial from FUBO)
The Dolphins will be angry after their embarrassing loss against the Bills. Advantage: Miami.
Prediction: Dolphins 34, Giants 21
New Orleans Saints at New England Patriots, 10 a.m., CBS (stream with free trial from FUBO)
Two struggling offenses square off, so this one might come down to which defense makes more plays. Give us the Saints.
Prediction: Saints 20, Patriots 16
Baltimore Ravens at Pittsburgh Steelers, 10 a.m., CBS (stream with free trial from FUBO)
The Ravens seemed to flip a switch offensively in their win over the Browns. That's bad news for the rest of the AFC North.
Prediction: Ravens 27, Steelers 17
NFL Week 5 schedule:Television channels, how to watch, how to stream games
Sunday late football games predictions
Cincinnati Bengals at Arizona Cardinals, 1:05 p.m., FOX (stream with free trial from FUBO)
We've picked against the Cardinals in every game this season. Not this game. The Bengals' woes will continue with a loss to Arizona.
Prediction: Cardinals 24, Bengals 16
Philadelphia Eagles at Los Angeles Rams, 1:05 p.m., FOX (stream with free trial from FUBO)
The Rams have surprised us with their play this season, but a win over the Eagles would really surprise us.
Prediction: Eagles 30, Rams 23
New York Jets at Denver Broncos, 1:25 p.m., CBS (stream with free trial from FUBO)
Zach Wilson appeared to take a step forward in the loss to the Chiefs in Week 4 for the Jets. We think he'll lead New York to a win in Week 5.
Prediction: Jets 20, Broncos 17
Kansas City Chiefs at Minnesota Vikings, 1:25 p.m., CBS (stream with free trial from FUBO)
We were not impressed with the Chiefs' play in the win over the Jets. They are ripe for another loss, with Justin Jefferson going off at home.
Prediction: Vikings 27, Chiefs 24
NFL Week 5 announcers:Television broadcasters, announcing crews for Week 5 NFL schedule
Sunday Night Football prediction
Dallas Cowboys at San Francisco 49ers, 5:20 p.m., NBC, Telemundo (stream with free trial from FUBO)
The game of the week. The Cowboys' defense is impressive, but the 49ers have Christian McCaffrey. We'll side with San Francisco.
Prediction: 49ers 27, Cowboys 23
Monday Night Football prediction
Green Bay Packers at Las Vegas Raiders, 5:15 p.m., ABC, ESPN, ESPN2, ESPN Deportes (stream with free trial from FUBO)
The Packers have had plenty of time to think about this one after losing in NFL Week 4 to the Lions. We'll go with the road team in Las Vegas.
Prediction: Packers 24, Raiders 16
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